Novel aspects of platelet factor XIII function
نویسندگان
چکیده
منابع مشابه
Novel aspects of platelet factor XIII function.
Pools of factor XIII (FXIII) exist in the plasma and within the cytoplasm of hematopoietic cells, including platelets. The functions of the cellular form, FXIII-A, have been assumed to be intracellular in nature, as the protein lacks a signal sequence for its release. Mounting evidence now suggests that platelet FXIII-A modulates hemostasis by several different mechanisms. In this condensed rev...
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PURPOSE OF REVIEW Here we review recent developments concerning the diagnosis, classification and treatment of factor XIII (FXIII) deficiency and new findings related to the pathogenesis of the disease. RECENT FINDINGS Most recently, the International Society on Thrombosis and Haemostasis, Scientific and Standardization Committee published a guideline for the diagnosis and classification of F...
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ژورنال
عنوان ژورنال: Thrombosis Research
سال: 2016
ISSN: 0049-3848
DOI: 10.1016/s0049-3848(16)30356-5